People with diabetes are often prone to dry skin on their feet due to a number of factors, including anhidrosis (the inability to sweat normally) which is commonly associated with diabetic neuropathy.1,2

Flexitol is a urea-based emollient (at 25% urea and 10% urea concentrations) that provides a medically proven regime for dry, cracked heels and feet associated with diabetic anhidrosis.1

Urea is a physiological substance that is widely used across the Flexitol range of products due to its highly hydrating and moisturising properties. It is a major constituent of the skin’s Natural Moisturising Factor (NMF) and is widely distributed within human tissue. In some dry skin conditions, urea appears depleted and so Flexitol 25% Urea Heel Balm replenishes these levels.

Being inherently hygroscopic, urea hydrates the skin by increasing the water uptake from the dermis layer of the skin and enhances the water-binding capacity of the stratum corneum.


Urea improves hydration by:

91% stated the recommended concentration of urea-based emollient for treatment of hyperkeratosis is 10–25%

Enhancing
the skin’s ability to retain water

84% stated people with diabetes and hyperkeratosis require daily application of urea-based emollient for use on the feet

Improving
the amount of water the skin can hold

91% stated the cost of preventing diabetes foot complications is lower than treating the consequences of foot complications

Reducing
water loss from the skin

91% stated the cost of preventing diabetes foot complications is lower than treating the consequences of foot complications

Removing
dead skin cells – keratolytic properties


Double-blind comparative study

In a double-blind comparative study, 30 outpatients with bilateral anhidrosis applied a 10% urea cream to the right foot and a 25% urea cream to the left foot, twice daily.

Results indicate that both creams increased skin hydration levels significantly, with the 25% urea cream showing an increase more than double that for the 10% urea cream.1

References
1. Baird S, et al. 2003. Anhydrosis in the Diabetic Foot: A Comparison of Two Urea Creams. The Diabetic Foot, Vol. 6 No. 3, 122-36.
2. Lower extremity amputation in diabetic patients. Lund University, Doctoral Thesis, 1994.

UK-FLEXRX-63eb | December 2023

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